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Mechanism of Leonurine in Alleviating Acute Lung Injury Induced by Paraquat Poisoning via Synergistically Regulating Ferroptosis and Endoplasmic Reticulum Stress Through the ATF4/CHOP Axis

Mechanism of Leonurine in Alleviating Acute Lung Injury Induced by Paraquat Poisoning via Synergistically Regulating Ferroptosis and Endoplasmic Reticulum Stress Through the ATF4/CHOP Axis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500115375
Enrollment
Unknown
Registered
2025-12-25
Start date
2026-01-01
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Paraquat poisoning

Interventions

Case Group:None
Healthy control group:None

Sponsors

Taizhou First People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria for the case group: 1. Clarify the history of paraquat poisoning (oral dose > 10 ml or positive paraquat test in blood/urine); 2. Hospitalization within 24 hours after poisoning; 3. Age: 18 to 65. Control group Healthy examinees with age and gender matching

Exclusion criteria

Exclusion criteria: 1. Combined with chronic lung diseases, malignant tumors, and immune system diseases; 2. Severe liver and kidney dysfunction already existed before poisoning.

Design outcomes

Primary

MeasureTime frame
mRNA and protein expression levels;—

Countries

China

Contacts

Public ContactCai Qiqi

Taizhou First People's Hospital

caiqiqi302@126.com+86 576 8423 0121

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026