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Effects of Patient-Controlled Intravenous Analgesia with Low-Dose Esketamine Combined with Nalbuphine on Postoperative Sleep and Pain after Cesarean Section: A Randomized, Double-Blind, Controlled Trial

Effects of Patient-Controlled Intravenous Analgesia with Low-Dose Esketamine Combined with Nalbuphine on Postoperative Sleep and Pain after Cesarean Section: A Randomized, Double-Blind, Controlled Trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500115366
Enrollment
Unknown
Registered
2025-12-25
Start date
2026-01-01
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sleep

Interventions

Esketamine combined with nalbuphine group:Sufentanil, esketamine and nalbuphine were used in the analgesia pump

Sponsors

Beijing Anzhen Nanchong Hospital of Capital MedicalUniversity&Nanchong Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. All included were full-term singleton pregnancies; 2. ASA classification is I-II level; 3. No history of drug allergies; 4. Pregnant women aged 20-45 years old; 5. All underwent cesarean section surgery; 6. Sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Have serious systemic diseases; 2. Pregnancy diabetes, hypertension; 3. There are contraindications for the use of drugs used in the experiment; 4. Individuals with mental illness, communication barriers, or mental disorders; 5. Allergies to opioids, sedatives, hypnotics, or psychotropic drugs, or a history of abuse of such drugs; 6. Preoperative heart rate<50 beats/min or pre anesthesia systolic blood pressure<100 mm Hg.

Design outcomes

Primary

MeasureTime frame
Sleep quality;

Secondary

MeasureTime frame
pain;Adverse reaction;Anxiety and depression score;

Countries

China

Contacts

Public ContactXie Ying

Beijing Anzhen Nanchong Hospital of Capital MedicalUniversity&Nanchong Central Hospital

475153895@qq.com+86 159 8377 6950

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026