Knee osteoarthritis
Conditions
Interventions
Healthy Control group:None
Sponsors
Shanghai Seventh people's hospital
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patient inclusion criteria: (1) Meeting the diagnostic criteria for knee osteoarthritis established by the American College of Rheumatology in 1986; (2) Age 50-75 years; (3) Disease duration exceeding 3 months and not in the acute phase; (4) Right-dominant and the affected area is the right knee joint; (5) Able to walk independently in the community; (6) Signed informed consent form. 2. Healthy control inclusion criteria: (1) Age range 50-75 years; (2) No history of chronic pain; (3) Right-dominant; (4) Signed informed consent form.
Exclusion criteria
Exclusion criteria: (1) Unstable angina or myocardial infarction within the past three months; (2) Resting heart rate greater than 120 bpm, systolic blood pressure greater than 180 mmHg, or diastolic blood pressure greater than 100 mmHg; (3) Acute chronic obstructive pulmonary disease (COPD) or other acute lung disease; (4) Clinically significant arrhythmia (e.g., atrial fibrillation); (5) Neurological disorders (e.g., stroke, multiple sclerosis, epilepsy, brain tumor or traumatic brain injury, spinal cord injury); (6) Musculoskeletal disorders affecting mobility: hip osteoarthritis, low back pain, lumbar radiculopathy/sciatica or lumbar stenosis; (7) Loss of sensation in the legs and feet; (8) Vascular diseases of the legs (e.g., Peripheral artery disease, venous disease); (9) Knee surgery within the past 6 months; (10) Previous hip or knee replacement surgery; (11) Lower limb or pelvic fracture or dislocation within the past 6 months; (12) Knee injection within the past 3 months; (13) History of cancer or currently undergoing cancer treatment; (14) Use of analgesics within one week prior to the test.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| movement-evoked pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Task-based electroencephalography (power spectral density, functional connectivity); | — |
Countries
China
Contacts
Public ContactLiming Jiang
Shanghai Seventh people's hospital
Outcome results
None listed