Sarcopenia
Conditions
Interventions
Sugammadex Sodium Group (Group S):After the operation, patients in Group S were transferred to the post-anesthesia care unit (PACU) and received an intravenous injection of sugammadex sodium at a dose
Neostigmine Group (Group N):After the operation, patients in Group N were transferred to the post-anesthesia care unit (PACU) and received an intravenous injection of neostigmine (0.04 mg/kg) combined
Sponsors
Anhui NO.2 Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1.Patients with unilateral hip fracture caused by falling injury, who underwent artificial femoral head replacement (AFHR) or proximal femoral nail antirotation (PFNA) surgery 2.Preoperative chest CT examination was performed to measure the skeletal muscle mass index (SMI) at the level of the 12th thoracic vertebra. For males: SMI < 42.6cm^2/m^2; For females: SMI < 30.6cm^2/m^2 3.Rocuronium or vecuronium was used as muscle relaxants during anesthesia induction and maintenance
Exclusion criteria
Exclusion criteria: 1. Pre-existing lower limb motor dysfunction, with a history of underlying diseases such as coronary heartdisease, cerebral infarction and stroke 2. Non-first-time hip fracture, traffic accident, multiple fractures, congenital or acquired hip dysplasia,pathological fracture 3.Non-AFHR Or PFNA surgical procedure 4. Conservative treatment 5.Cisatracurium besilate was selected for induction 6. Severe hepatic and renal insufficiency 7. Allergic to related drugs, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time for the train-of-four ratio (TOFr) to recover to 0.9 after drug administration and the time from the end of surgery to extubation;TOFr at the time of extubation;Duration of PACU Stay;Record the occurrence of post-extubation hypoxemia (SpO? < 90%) and calculate the incidence of residual neuromuscular block (RNMB: TOFr < 0.9 at extubation);Evaluate and record the maximum grip strength before the usual surgery, 5 minutes after extubation, and upon discharge from the PACU, then calculate the differences.;The occurrence of postoperative pulmonary complications (PPCs) from the end of surgery to prior to hospital discharge; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total number of presses, number of effective presses, and number of rescue analgesia administrations of the patient-controlled analgesia (PCA) pump within 48 hours after surgery;Number of cases of postoperative nausea and vomiting (PONV);Incidence of other adverse reactions (such as arrhythmia, dizziness, fever, etc.);The condition of the first postoperative ambulation and the duration of postoperative hospital stay; | — |
Countries
China
Contacts
Public ContactLi Tao
Anhui NO.2 Provincial People's Hospital
Outcome results
None listed