Autoimmune pancreatitis
Conditions
Interventions
Low-dose GC group:None
High-dose GC group:None
Medium-dose GC group:None
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Patients aged between 18 and 75 years, regardless of gender, who meet the diagnostic criteria for type 1 autoimmune pancreatitis (AIP): The diagnostic criteria are based on the guidelines for the diagnosis and treatment of autoimmune pancreatitis in China (Shanghai, 2023); 2.Patients diagnosed with type 1 AIP who are initially receiving treatment for induction of remission and have not previously received treatment with hormones, immunosuppressants, or B cell-targeting biological agents.
Exclusion criteria
Exclusion criteria: 1.Comorbidities of diseases similar to IgG4: such as Sjogren's syndrome, granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, etc.; 2.Presence of malignant tumors; 3.Presence of severe and irreversible organ damage: referring to severely compromised organ function due to disease or previous treatment (meeting any of the following criteria), with particular attention to damage of the following organs (including but not limited to): liver, kidneys, heart, central nervous system; (1) Liver: Child-Pugh classification >= B or MELD score >= 15; (2) Kidneys: CKD stage 4-5 (eGFR = III or echocardiogram suggesting LVEF <= 35%; (4) Central nervous system: GCS score less than 15; 4.Presence of active infection (defined as an infection requiring intravenous antibiotic treatment or hospitalization); 5.Pregnancy or breastfeeding; 6.The investigator deems the subject unsuitable for inclusion in this study; 7. Age under 18 or over 75; 8. History of treatment with hormones, immunosuppressants, or B-cell targeted biologics
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Remission rates at weeks 12, 24, and 52; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum IgG level, serum IgG4 level;Adverse drug reactions;Length of stay and expenses;Complications, types and severity; | — |
Countries
China
Contacts
Public ContactAiming Yang
Peking Union Medical College Hospital
Outcome results
None listed