Effect of Abdominal Autonomic Nerve Block on Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Sleeve Gastrectomy

Effect of Laparoscopic Autonomic Nerve Block on Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Sleeve Gastrectomy

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500115339

Enrollment

Unknown

Registered

2025-12-24

Start date

2025-12-24

Completion date

Unknown

Last updated

2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Morbid Obesity

Interventions

CPB group (Celiac Plexus Block Group):At the beginning of surgery, laparoscopic celiac plexus block is performed by injecting 10 mL of 0.5% ropivacaine combined with 5 mg dexamethasone into the region

VNB group (Abdominal Vagal Nerve Block Group):At the beginning of surgery, laparoscopic vagal nerve block is performed by injecting 10 mL of 0.5% ropivacaine combined with 5 mg dexamethasone into the

Control group:At the beginning of surgery, 10mL of normal saline is injected under direct laparoscopic visualization into either the region of the celiac sympathetic plexus adjacent to the left gastri

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18–60 years. 2. American Society of Anesthesiologists (ASA) physical status class II–III. 3. Patients scheduled to undergo laparoscopic sleeve gastrectomy.

Exclusion criteria

Exclusion criteria: 1. Long-term use of corticosteroids or antiemetic medications. 2. Patients with severe cardiovascular diseases. 3. Patients receiving invasive mechanical ventilation preoperatively.

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative nausea and vomiting ;	—

Secondary

Measure	Time frame
Severity of PONV occurrence;Time to first episode of postoperative nausea and vomiting after surgery;Heart rate variability from pre-anesthesia to 24 hours postoperatively;Time to first postoperative flatus;Duration of surgery;Intraoperative opioid consumption;Opioid consumption within 24 hours after surgery;Antihypertensive drug consumption within 24 hours after surgery;Postoperative in-hospital complications;Length of hospital stay;Plasma inflammatory cytokine concentrations at the end of surgery;Plasma concentrations of catecholamine metabolites at the end of surgery;Plasma concentrations of neurotransmitters associated with postoperative nausea and vomiting at the end of surgery;	—

Measure

Time frame

Severity of PONV occurrence;Time to first episode of postoperative nausea and vomiting after surgery;Heart rate variability from pre-anesthesia to 24 hours postoperatively;Time to first postoperative flatus;Duration of surgery;Intraoperative opioid consumption;Opioid consumption within 24 hours after surgery;Antihypertensive drug consumption within 24 hours after surgery;Postoperative in-hospital complications;Length of hospital stay;Plasma inflammatory cytokine concentrations at the end of surgery;Plasma concentrations of catecholamine metabolites at the end of surgery;Plasma concentrations of neurotransmitters associated with postoperative nausea and vomiting at the end of surgery;

—

Countries

China

Contacts

Public ContactLiu Shaozhuang, Liu Wanling

Qilu Hospital of Shandong University

liuwanling@qiluhospital.com+86 185 6008 8228

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026