Burning mouth syndrome
Conditions
Interventions
Melatonin + alpha-lipoic acid (ALA) group:Take alpha-lipoic acid (ALA), which is currently commonly used to treat BMS, three times a day, 200mg each time, for four consecutive weeks. And take melaton
Alpha-lipoic acid (ALA) group:Take alpha-lipoic acid (ALA), which is currently commonly used to treat BMS, three times a day, 200mg each time, for four consecutive weeks.
Sponsors
West China School/Hospital of Stomatology, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: The inclusion criteria for participants in this experiment are as follows: Patients over 18 years old who meet the diagnostic criteria for BMS in the 3rd edition of the International Classification of Headache Diseases (ICHD-3) (International Headache Classification Committee, 2013); Chronic oral and facial pain recurs daily, accompanied by a burning sensation or discomfort on the surface of the oral mucosa, lasting for more than 2 hours per day for more than 3 months. The appearance of the oral mucosa is normal clinical examinations, including sensory tests, were normal. Another ICHD-3 diagnosis does not better explain the condition.
Exclusion criteria
Exclusion criteria: 1. Secondary BMS caused by local (candidiasis, lichen planus, etc.) or systemic diseases (hypothyroidism, diabetes, etc.); 2.Currently taking anti-anxiety drugs to induce sleep, antidepressants, anticonvulsants or psychotropic drugs; 3. There has been a history of exogenous melatonin use within the past 3 months; 4. Oral cavity patients with poor hygiene; 5.Patients with abnormal blood test results (including blood cell count, glucose, serum iron, ferritin and transferrin, folic acid or vitamin B12 levels); 6.Have been or are currently undergoing plant-based therapy or dietary supplement treatment containing melatonin, serotonin and tryptophan; 7. Working at night, traveling or on business across time zones; 8. Currently receiving anticoagulant drug treatment; 9.Patients with incomplete personal medical records; 10.Patients who are unwilling to participate in the study; 11. Patients who cannot adhere to completing the research requirements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale Scores; | — |
Countries
China
Contacts
Public ContactJiang Lu
West China School/Hospital of Stomatology, Sichuan University
Outcome results
None listed