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Exploring the Role of the Left Anterior Temporal Lobe in Semantic Processing for Naming Impairment in Mild Cognitive Impairment Patients Using fNIRS

Exploring the Role of the Left Anterior Temporal Lobe in Semantic Processing for Naming Impairment in Mild Cognitive Impairment Patients Using fNIRS

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500115322
Enrollment
Unknown
Registered
2025-12-24
Start date
2025-06-17
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild Cognitive

Interventions

MCI-Anomia Group:None
MCI-Non-Anomia Group:None
Normal Control Group:None

Sponsors

Fujian University of Traditional Chinese Medicine Rehabilitation Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to No maximum

Inclusion criteria

Inclusion criteria: Elderly with MCI 1. Patients meeting the diagnostic criteria for Mild Cognitive Impairment (MCI); 2. Aged >=60 years; right-handed (assessed using the Edinburgh Handedness Inventory); 3. Provide informed consent and voluntarily participate. Cognitively Normal Elderly 1.Cognitively normal elderly individuals with a Montreal Cognitive Assessment (MoCA) score >=26; 2. Aged >=60 years; right-handed (assessed using the Edinburgh Handedness Inventory); 3. Possess normal activities of daily living and are able to care for themselves either fully or with minimal assistance; 4. Have provided informed consent and participate voluntarily.

Exclusion criteria

Exclusion criteria: 1.History of depression or a score >=9 on the Geriatric Depression Scale-Short Form (GDS-SF); 2.Cognitive impairment caused by medications (e.g., antipsychotics, benzodiazepines), poisoning, inflammatory cerebrovascular disease, encephalitis, brain tumors, traumatic brain injury, epilepsy, Parkinson’s disease, or other neurological/medical conditions; 3.Severe systemic diseases (e.g., cardiac/hepatic/renal failure, malignant tumors); 4.History of brain tumors, cerebral infarction, cerebral hemorrhage, intracranial infection, epilepsy, or other neurological disorders; 5.Severe visual, auditory, or language impairments preventing cooperation with cognitive assessments; 6.Dementia of any etiology.

Design outcomes

Primary

MeasureTime frame
Montreal Cognitive Assessment;Boston Naming Test;Functional Near-Infrared Spectroscopy;

Secondary

MeasureTime frame
Semantic Fluency Test;Rey Auditory Verbal Learning Test;Cognitive Reserve Questionnaire ;

Countries

China

Contacts

Public ContactZuo Shuang

Fujian University of Traditional Chinese Medicine Rehabilitation Hospital

2507285099@qq.com+86 137 3905 2556

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026