High-risk human papillomavirus
Conditions
Interventions
Observation group:None
Focused Ultrasound Group:None
Cervical Conization Group:None
Sponsors
Chuanbei Medical College Affiliated Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Focused Ultrasound Group: 1. Persistent high-risk HPV infection; 2. HR-HPV infection combined with cervicitis; 3. Persistent LSIL (CIN1) or LSIL (CIN1) with clinical symptoms; 4. Negative cervical canal curettage (ECC) pathological histological examination; 5. Satisfactory colposcopy for HSIL (CIN2, CIN3). Cervical Conization Group: 1. Preoperative cervical biopsy pathologically diagnosed as HSIL, and cervical conization performed at our hospital, with postoperative pathological results indicating HSIL, LSIL, or chronic cervicitis with negative margins; 2. Desire to preserve the uterus and age between 20-44 years; 3. Regular follow-up after surgery; 4. No vaginal douching, sexual activity, or vaginal medication within 48 hours before examination. Observation Group: 1. Patients diagnosed with cervicitis or low-grade cervical intraepithelial neoplasia based on HPV-DNA testing, liquid-based cytology, colposcopy, cervical biopsy, medical history inquiry, and routine examinations; 2. Patients aged <=25 years with cervical pathology indicating HSIL (CINII) and negative cervical curettage specimens.
Exclusion criteria
Exclusion criteria: Focused Ultrasound Group: 1. Cervical glandular lesions; 2. Persistent or recurrent lesions after HSIL treatment, with inconsistent cytology, colposcopy, and pathological diagnosis; 3. Lesion area exceeding 75% of the cervical area; 4. Accompanied by acute genital tract inflammation; 5. Recurrence detected during follow-up requiring repeat cervical conization or total hysterectomy; 6. Request for total hysterectomy during follow-up; 7. History of previous cervical surgery or cervical physical therapy; 8. Malignant tumors. Cervical Conization Group: 1. Recurrence detected during follow-up requiring repeat cervical conization or total hysterectomy; 2. Request for total hysterectomy during follow-up; 3. Undergoing treatment for acute genital organ inflammation; 4. Malignant tumors. Observation Group: 1. Recurrence detected during follow-up requiring repeat cervical conization or total hysterectomy; 2. Request for total hysterectomy during follow-up; 3. Undergoing treatment for acute genital organ inflammation; 4. History of previous cervical surgery or cervical physical therapy; 5. Accompanied by malignant tumors; 6. HSIL (CIN3) or cervical malignancy; 7. HSIL (CIN2) patients aged =25 years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anxiety state and anxiety events;Treatment decision;Disease burden; | — |
Countries
China
Contacts
Public ContactZhang Miao
Chuanbei Medical College Affiliated Hospital
Outcome results
None listed