Postoperative cognitive dysfunction (POCD)
Conditions
Interventions
non-POCD group:NA
POCD group:NA
norm group:NA
Sponsors
People's Hospital of Jianyang City
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=60 years , any sex. 2. American Society of Anesthesiologists (ASA) physical status classification I–III. 3. Meet the indications for the corresponding major orthopedic lower-limb surgery and are scheduled for surgery under general anesthesia.
Exclusion criteria
Exclusion criteria: 1. Severe cognitive impairment already present before surgery. 2. A clear history of neurological disease that significantly affects cognitive assessment. 3. A history of severe psychiatric illness. 4. Preoperative anxiety/depressive symptoms that significantly affect cognitive assessment. 5. Patients who abuse drugs or who are on long-term medications that affect cognitive function. 6. Patients who refuse to participate, are unable to communicate, or cannot cooperate to complete blood specimen collection or otherwise cannot undergo cognitive function assessment. 7. Patients deemed unsuitable for participation in this study by the principal investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Circadian Rhythm-Related Differentially Expressed Gene mRNA Expression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Baseline clinical data;Perioperative Data;Incidence of postoperative cognitive dysfunction;Cognitive Function Score;levels of inflammatory factors;Circadian Rhythm Types and Sleep Quality Assessment; | — |
Countries
China
Contacts
Public ContactZhong Qing
People's Hospital of Jianyang City
Outcome results
None listed