Alzheimers disease and related dementias
Conditions
Interventions
Mild Behavioral Impairment Group (MBI):None
Health Control Group:None
Sponsors
Shanghai Mental Health Center
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: MBI Enrollment Criteria: 1. Age >=50 years and =50 years and <=80 years; 2. Signed informed consent; 3. Able to cooperate and complete neuropsychological scale assessments, biological sample collection, and imaging examinations. 4. Community-dwelling middle-aged and elderly individuals without a psychiatric diagnosis according to ICD-10 standards, matched for age and gender with the disease group, who have provided signed informed consent.
Exclusion criteria
Exclusion criteria: MBI Group Exclusion Criteria: 1. Cerebral infarction or cerebral hemorrhage; 2. Intracranial tumors, inflammation, traumatic brain injury, epilepsy, etc.; 3. White matter lesions caused by other reasons (e.g., multiple sclerosis, sarcoidosis, etc.); 4. Chronic diarrhea or malnutrition (vitamin deficiency), thyroid dysfunction, hepatic or renal insufficiency, history of blood transfusion, history of high-risk sexual behavior, alcoholism, carbon monoxide poisoning, severe cardiopulmonary disease, drug abuse, etc.; 5. Autism and other psychiatric disorders; 6. MRI contraindications (e.g., cardiac pacemaker, metal clips, etc.). Healthy Control Group Exclusion Criteria: 1. Individuals currently, previously, or suspected of having a mental disorder. 2. Presence of clinically significant diseases, such as a history of cardiovascular, hepatic, endocrine, gastrointestinal, metabolic, neurological, pulmonary, psychiatric, or oncological diseases, or any clinically significant condition or other evidence that the investigator believes poses a risk to the subject's safety or may interfere with the initiation, conduct, or completion of the study. 3. Subjects whom the investigator deems unsuitable to participate in this trial due to other factors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of Mild Behavioral Impairment Score;Changes in Cognitive Function Scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change of Severity of Depression;Change of Self-Rating Anxiety Score;Change of Social Function Score;Change of sleep sccore;Change of Activities of Daily Living; | — |
Countries
China
Contacts
Public ContactLing Yue
Shanghai Mental Health Center
Outcome results
None listed