Major Depressive Disorder
Conditions
Interventions
Cross-frequency coupling transcranial alternating current stimulation (CFC-tACS) group A:The CFC-tACS group A was given delta-beta CFC-tACS real stimulation for 1 weeks, 10 times a week, and each sti
Cross-frequency coupling transcranial alternating current stimulation (CFC-tACS) group B:The CFC-tACS group B was given theta-gamma CFC-tACS real stimulation for 1 weeks, 10 times a week, and each st
sham group C:The sham group C was given sham stimulation for 1 weeks, 10 times a week, and each stimulation lasted 20 minutes.
Sponsors
Tianjin Anding Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for "Depressive Disorders" in the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), and require that all patients' diagnoses be independently confirmed by at least two attending psychiatrists or higher-level psychiatric physicians, currently in a depressive episode; 2. Age 18-50 years; 3. No gender restriction; 4. Education level of junior high school or above; 5. Normal hearing and vision or corrected normal hearing and vision; 6. Have not used antidepressants for at least 2 weeks before enrollment; 7. Patients can read and understand the informed consent form, self-assessment scales, etc., on their own; 8. Patients or their family members agree to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. A history of mental genetic disorders meeting DSM-5 criteria, or a diagnosis of other mental disorders except for 'depressive disorders'; 2. Accompanied by cranial trauma or a history of coma; 3. Accompanied by organic brain disease or severe physical illnesses; 4. Previously implanted with a cochlear implant, cardiac pacemaker, or any brain device or implant; 5. A history of epilepsy or a family history of epilepsy; 6. Significant suicidal or impulsive harmful behaviors; 7. Received physical treatments such as electroconvulsive therapy without seizures or transcranial magnetic stimulation within the past six months; 8. History of alcohol abuse or use of other psychoactive substances; 9. Currently participating in other drug clinical trials; 10. Any factors that hinder participants from providing informed consent or participating in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Rating Scale (HAMD-17) score;Patient Health Questionnaire-9 (PHQ-9) score;Cognitive Flexibility Inventory score;Emotion Regulation Questionnaire;Non-invasive Electroencephalography (EEG);Non-contact Eye-tracking Signals; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale (HAMA) score;Young Mania Rating Scale (YMRS) score;Generalized Anxiety Disorder (GAD-7) score;Hypomania Checklist (HCL-33) score;Cognitive Reappraisal Function;Ruminative Response Scale;Difficulties in Emotion Regulation Scale; | — |
Countries
China
Contacts
Public ContactMeijuan Li
Tianjin Anding Hospital
Outcome results
None listed