Depression
Conditions
Interventions
Healthy controls group :N/A
Sponsors
Zhongda Hospital Affiliated to Southeast University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria for Patient Group: 1. Hospitalized patients. 2. Aged 18-65 years (inclusive), regardless of gender. 3. Meet the diagnostic criteria for Major Depressive Disorder (MDD) as per DSM-5. 4. Screening and baseline Hamilton Depression Rating Scale (HAMD-24) total score >=20. 5. No history of electroconvulsive therapy (ECT). 6. No use of psychiatric medications within two weeks prior to enrollment. 7. No use of medications known to affect gut microbiota within one week prior to enrollment. 8. Informed consent form signed by the patient or their legal guardian. Inclusion Criteria for Healthy Control Group: 1. Healthy individuals matched to the patient group for gender, age, and education level, with a HAMD-24 total score < 8. 2. No history of severe cardiac, cerebral, or renal diseases. 3. No history of alcohol or substance abuse. 4. No family history of mental disorders. 5. Informed consent form signed by the individual or their legal guardian.
Exclusion criteria
Exclusion criteria: Exclusion Criteria for Patient Group: 1. History of schizophrenia, alcohol, or substance dependence. 2. Presence of severe suicidal behavior or ideation. 3. History of organic brain disease. 4. Severe abnormalities in cardiac, hepatic, or renal function. 5. Women who are pregnant or breastfeeding. 6. Patients with metabolic syndrome (e.g., diabetes, pathological obesity, etc.). 7. Presence of severe gastrointestinal diseases or a history of relevant surgeries affecting gastrointestinal function. 8. Use of medications known to affect gut microbiota within the past 3 months. Exclusion Criteria for Healthy Control Group: 1. History of schizophrenia, alcohol, or substance dependence. 2. History of organic brain disease. 3. Severe abnormalities in cardiac, hepatic, or renal function. 4. Women who are pregnant or breastfeeding. 5. Individuals with metabolic syndrome (e.g., diabetes, pathological obesity, etc.). 6. Presence of severe gastrointestinal diseases or a history of relevant surgeries affecting gastrointestinal function. 7. Use of medications known to affect gut microbiota within the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton depression scale ;Hand Microbiota;Gut microbiota ;Metabolites;CircRNA; | — |
Countries
China
Contacts
Public ContactYonggui Yuan
Zhongda Hospital Affiliated to Southeast University
Outcome results
None listed