Hereditary venous thromboembolism
Conditions
Interventions
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years old; 2. Diagnosis of VTE (DVT/PE); 3. Genetic testing confirmed the presence of hereditary thrombophilia (such as F5/F2 mutations or defects in natural anticoagulant proteins); 4. Plans to undergo long-term treatment with NOACs (rivaroxaban/edoxaban/dabigatran) for more than 6 months; 5. Can understand and sign the informed consent form, and are willing to cooperate throughout the entire research process.
Exclusion criteria
Exclusion criteria: 1. Active bleeding or contraindications to anticoagulation; 2. Severe liver and kidney dysfunction (CrCl < 30 ml/min); 3. Pregnancy or lactation period; 4. Expected survival period < 6 months;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recurrent thrombosis rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence rate of major bleeding events; | — |
Countries
China
Contacts
Public ContactYan Zhou
Shanghai General Hospital
Outcome results
None listed