postherpetic neuralgia
Conditions
Interventions
treatment group:Receive a single short-duration (2-week) dorsal root ganglion stimulation (DRGS) treatment while continuing oral pregabalin (150 mg, BID). After electrode implantation, the patient wil
Control Group:Continue oral pregabalin (150 mg, BID) for 14 weeks to complete the follow-up.
Sponsors
Shanghai East Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age>=18 years. 2. Persistent pain following healing of cutaneous lesions from thoracic-segment (T2-T11) herpes zoster. 3. Pain Numeric Rating Scale (NRS) score >= 4. 4. Ability to provide written informed consent for study participation, understand the study procedures, and adequately complete patient-reported questionnaires. 5. Tolerate oral pregabalin 150 mg twice daily during the medication washout/observation period, and have an Average Daily Pain Score (ADPS) >= 4 at the end of this period.
Exclusion criteria
Exclusion criteria: 1. Presence of local or systemic infection at the intended puncture site; 2. Coagulation dysfunction (INR > 1.4 or platelet count 10% at screening or uncontrolled blood glucose within the preceding 1 month; 5. Other severe pain, neurological disorders, or dermatological conditions unrelated to postherpetic neuralgia that may interfere with assessment; 6. Implanted electronic devices such as cardiac pacemakers; 7. Severe cardiac, hepatic, or renal insufficiency; 8. Uncontrolled severe psychiatric illness or cognitive impairment; 9. Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weekly Average Daily Pain Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Weekly Average Daily Pain Score;Weekly Average Daily Pain Score (ADPS) Response Rate;Neuropathic Pain Scale(NPS);Pain Catastrophizing Scale,PCS;Hospital Anxiety and Depression Scale;Pittsburgh Sleep Quality Index;Patient Global Impression of Change (PGIC);Rescue medication; | — |
Countries
China
Contacts
Public ContactLiao Lijun
Shanghai East Hospital
Outcome results
None listed