(Within 24 hours of onset) Acute cerebral infarction, acute ischemic stroke.
Conditions
Interventions
Experimental group:Intravenous infusion of tirofiban for the first 48 hours
control group:Traditional oral dual antiplatelet therapy: Take aspirin 100 mg daily, clopidogrel 75 mg twice a day, and receive intravenous placebo for 2 days.
Sponsors
Hengzhou People’s Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 65 years old, able to live and work independently before the onset, acute cerebral infarction occurred within 24 hours after the onset, and NIHSS score >= 2 point ,ands after the onset; 2. CT scan shows that the volume of the intracranial low-density lesion is less than 1/3 of the MCA blood supply area; 3. ASPECTS score >= 3 points (or pc-ASPECTS score >= 6 points); 4. Within 24 hours of onset, there was a progression of symptoms after endovascular treatment (defined as an increase in the NIHSS score from baseline of >= 2 points); 5. Receive intravenous thrombolysis, but if there is no improvement in neurological function within 2 to 24 hours after thrombolysis, it is defined as a decrease in the NIHSS score from the baseline of less than 2 points.
Exclusion criteria
Exclusion criteria: 1. Having a history of severe trauma or stroke within the past three months; 2. Those with intracranial hemorrhage or more than 10 intracranial microbleeds; 3. Patients who are currently taking warfarin; 4. Using thrombolytic drugs within two hours; 5. Patients with definite cardiogenic embolism; 6. Hemorrhagic disorders: Hemophilia, active ulcers, active internal bleeding; 7. Intracranial tumors, cerebral arteriovenous malformations; 8. There is a history of platelet reduction after using tirofiban; 9. Platelet reduction; 10. Allergic constitution; 11. Expected lifespan is less than 90 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The proportion of patients with a modified Rankin Scale (MRS) score of= 4 points); | — |
Secondary
| Measure | Time frame |
|---|---|
| Intracranial symptomatic and asymptomatic hemorrhage;blood platelet count;The incidence of early neurological deterioration;24-hour improvement rate of HIHSS (reduction of >= 4 points); | — |
Countries
China
Contacts
Public ContactQinian Chen
Hengzhou People’s Hospital
Outcome results
None listed