Cancer pain
Conditions
Interventions
Morphine ER Group:Equivalent rotation of oxycodone with Morphine Sulfate Extended-release Tablets
Hydromorphone group:Equivalent rotation of oxycodone with OROS Hydromorphone
Sponsors
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.aged >=18 years; 2.patients with cancer pain; 3.Oxycodone hydrochloride sustained-release tablets are used for the management of cancer-related pain; 4.Inadequate control of cancer pain with a daily resting Numeric Rating Scale (NRS) score persistently >= 4, and the occurrence of more than three episodes of breakthrough pain
Exclusion criteria
Exclusion criteria: 1.Severe respiratory compromise or severely depressed ventilatory function, impaired renal, cardiac or hepatic function,; 2.Use of monoamine oxidase inhibitors within 2 weeks prior to study entry; 3.Presence of conditions for which risks of opioid use outweigh potential benefits (e.g., raised intracranial pressure, hypotension, hypothyroidism, asthma, reduced respiratory reserve, prostatic hypertrophy, hepatic impairment, renal impairment, elderly and debilitated, convulsive disorders, Addison's disease); 4.Current or recent (within 6 months) history of drug and/or alcohol abuse; 5.Pure neuropathic pain or pain of unknown causes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time (in days) required to titrate the dosages of the two drugs to achieve adequate analgesic effect; | — |
Secondary
| Measure | Time frame |
|---|---|
| The occurrence of adverse drug reactions (nausea, vomiting, drowsiness, constipation);The most severe pain score in the past 24 hours (patients self-assessment through a questionnaire-based brief pain inventory, BPI);The current impact of cancer pain on daily life; | — |
Countries
China
Contacts
Public ContactJiao Zhang
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Outcome results
None listed