Parkinson‘s disease
Conditions
Interventions
Control group:No
Sponsors
The First Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
45 Years to 95 Years
Inclusion criteria
Inclusion criteria: 1. Basic Inclusion Criteria: (1) Ability to sign a written informed consent form: The subject and/or their legally authorized representative (in cases of reduced decision-making capacity), in compliance with national laws, must be able to read, understand, and provide written informed consent. (2) Ability to complete assessments independently or with the assistance of a companion. (3) Willingness and capability to fulfill all study requirements (e.g., peripheral organ function evaluations, PET imaging for some patients, etc.). (4) Age between 45 and 95 years. 2. Normal Control Group Inclusion Criteria: (1) Similar age distribution and gender ratio to the Parkinson's disease (PD) group. (2) Non-Parkinson’s individuals from ophthalmology clinics, health examination centers, community settings, and some neurology clinic patients (e.g., those with tension-type headache or diabetic peripheral neuropathy), confirmed by a negative DaTscan result indicating no nigrostriatal impairment. 3. Parkinson's Disease Group Inclusion Criteria: Meet the clinical diagnostic criteria for Parkinson’s disease as established by the International Movement Disorder Society (MDS) in 2015.
Exclusion criteria
Exclusion criteria: (1) Refusal to sign the informed consent form; (2) Inability to cooperate with the completion of relevant scale assessments; (3) Presence of end-stage major systemic diseases (e.g., malignant tumors or autoimmune diseases) at the time of enrollment; (4) Psychiatric disorders (e.g., depression, schizophrenia); (5) Severe systemic diseases (e.g., diabetic retinopathy, autoimmune disorders, end-stage malignancies); (6) Ocular diseases that may affect OCT results (e.g., glaucoma, macular degeneration, high myopia exceeding -6.00 diopters, severe cataracts); (7) History of neurological disorders relevant to PD pathology (e.g., multiple sclerosis, Alzheimer's disease, stroke, epilepsy).
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Positive Likelihood Ratio/Negative Likelihood Ratio/Diagnostic Odds Ratio;Calibration;Sensitivity/Specificity/Negative Predictive Value/Positive Predictive Value;Area Under the Curve; | — |
Countries
China
Contacts
Public ContactYang Zhang
The First Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed