treatment-resistant depression
Conditions
Interventions
control group:Peripheral venous infusion of esketamine (with an anesthetic dose of 0.2mg/kg) for 40 minutes
Optimized treatment group:Peripheral intravenous infusion of esketamine (with an anesthetic dose of 0.2mg/kg) was administered for 40 minutes. Then, propofol was intravenously injected at a rate of 2-
Sponsors
Changzhou NO.2 People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Clinically diagnosed by a psychiatrist as a depressive disorder without psychotic symptoms, and in accordance with the DSM-5 (the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders) of the United States for depressive disorders without psychotic symptoms; 2. Total score of the Montgomery-Asberg Depression Rating Scale (MADRS) of 22 or above; 3. Understand the research content and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Suffering from other severe mental disorders that meet the diagnostic criteria of DSM-5, including schizophrenia, schizoaffective disorder, bipolar disorder, etc.; 2. History of severe physical or brain organic diseases, history of head trauma and epilepsy; 3. History of drug, alcohol or other psychoactive substance abuse; 4. History of previous anesthetic drug allergy; 5. Pregnant or lactating women or those planning to get pregnant; 6. Other conditions that the researcher deems inappropriate for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montgomery–Asberg Depression Rating Scale;Separation Status Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood pressure;heart rate ; | — |
Countries
China
Contacts
Public ContactLu Yanfeng
Changzhou NO.2 People's Hospital
Outcome results
None listed