Total knee arthroplasty
Conditions
Interventions
Control Group (S Group, sufentanil 0.06 µg/kg·h + ondansetron 12mg + flurbiprofen ester 150mg + 0.9%NS,150ml in total):The group receive PCIA for postoperative analgesia after surgery, and set the dos
Low concentration group (T1 Group, tegileridine 0.9 µg/kg·h + ondansetron 12mg + flurbiprofen ester 150mg + 0.9%NS,150ml in total):The group receive PCIA for postoperative analgesia after surgery, and
Medium concentration group (T2 Group, tegileridine 1.2 µg/kg·h + ondansetron 12mg + flurbiprofen ester 150mg + 0.9%NS,150ml in total):The group receive PCIA for postoperative analgesia after surgery,
High concentration group (T3 Group, tegileridine 1.5 µg/kg·h + ondansetron 12mg + flurbiprofen ester 150mg + 0.9%NS,150ml in total):The group receive PCIA for postoperative analgesia after surgery, an
Sponsors
Lu'an Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Elderly patients undergoing elective total knee arthroplasty; 2. ASA classification I–III, age >= 65 years, and 18.5 <= BMI < 30; 3. Willing to participate in the study and have signed the informed consent form; 4. Capable of understanding and cooperating with the administration of questionnaires and scales used in this study.
Exclusion criteria
Exclusion criteria: 1. Those who are allergic to the study drug used in this experiment; 2. Those who have been taking sedative drugs and antipsychotic drugs for a long time; 3. Those who have been taking opioid drugs for a long time; 4. Patients with severe systemic diseases of the heart, brain, liver, kidneys, etc
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Analgesic effect VAS score;Sedative effect Ramsay score; | — |
Secondary
| Measure | Time frame |
|---|---|
| PCIA press frequency within 48 hours after the operation ; | — |
Countries
China
Contacts
Public ContactLi Renhu
Lu'an Hospital of Anhui Medical University
Outcome results
None listed