Elderly patients with hypertension
Conditions
Interventions
Intervention group:Anesthesia induction using remimazolam
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Elderly patients with hypertension (aged 65-80 years, gender not limited) who are scheduled to undergo non-cardiac surgery under general anesthesia should take their medication regularly. 2. American Society of Anesthesiologists (ASA) grade II - III; 3. Be capable of accepting rapid induction of general anesthesia with tracheal intubation; 4. Be aware of and agree to participate in the trial and sign a written informed consent form; 5. BMI 18-30 kg/m^2.
Exclusion criteria
Exclusion criteria: 1.history of cerebral or thoracic/abdominal aortic aneurysm; 2.allergy to any drugs administered in the study; 3.history of severe liver impairment,namely, ChildePugh class C; 4.currently undergoing maintenance dialysis; 5.congestive heart failure, namely, New York Heart Association classification III or IV, untreated or unstable ischaemic heart conditions;history of multiple premature ventricular contractions, multiple atrial premature contractions, or atrial fibrillation, severe sinus bradycardia (heart rate =180 mmHg and/or diastolic blood pressure >=110 mmHg; 9.unsuccessful initial intubation, presence or anticipation of airway management difficulties; 10.Frailty (with a FRAIL Scale score of 3-5).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hypotension after general anesthesia induction; | — |
Secondary
| Measure | Time frame |
|---|---|
| maximum MAP after tracheal intubation;time from initiation of anaesthetic administration until LoC;number of administrations of vasopressor; | — |
Countries
China
Contacts
Public ContactLijian Chen
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed