Tuberculosis
Conditions
Interventions
Gold Standard:1. Microbiological standard: positive sputum culture
2. Molecular biological standard: sputum Xpert MTB/RIF was positive
3. Clinical diagnostic criteria: The expert group comprehensively judged active pulmonary tuberculosis according to imaging and treatment response.
Index test:Fluorescence quantitative PCR detection based on tongue swab
Sponsors
Huzhou Center Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Suspected symptoms of tuberculosis, including fever, chest pain, chest tightness, cough, expectoration or hemoptysis; 2. Imaging shows that there are lung lesions, and the specific characteristics should meet any of the following: cavity, bronchiectasis, nodular mass or scattered patchy ground glass shadow, patchy shadow in lung and bronchial disseminated focus, other special types, such as "hot water bath" lung, solitary nodule, etc. 3. Have been treated with anti-tuberculosis drugs for less than two weeks (recurrence is recalculated from suspected recurrence); 4.18 years old or above.
Exclusion criteria
Exclusion criteria: 1. Did not get enough samples of pathogens as expected; 2. Extrapulmonary tuberculosis; 3. Patients under the age of 18 or pregnant women and those who are underweight.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tongue swab of mycobacterium tuberculosis DNA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sensitivity of sputum for MTB detection;Adverse Event Rate;Oral microbiota profile; | — |
Countries
China
Contacts
Public ContactSong Qun
Huzhou Center Hospital
Outcome results
None listed