Patients with gastrointestinal diseases or normal individuals who need a physical examination
Conditions
Interventions
Control group:Anesthesia induction was initiated 5 minutes after starting nasal cannula oxygenation, with propofol administered intravenously at a dose of 1.5 mg/kg. The propofol dosage was adjusted b
Esketamine Group:After 5 minutes of nasal cannula oxygenation, anesthesia induction was initiated with intravenous propofol at a dose of 1.5 mg/kg. The propofol dosage was adjusted based on the target
Sponsors
Tianjin Binhai New Area Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years old; 2. BMI 18~25 kg/m²; 3. ASA I or II grade; 4. No history of allergy to the drugs involved in this study; 5. No history of allergy to the coupling agent; 6. The patient is mentally clear and voluntarily signs the informed consent form for this trial.
Exclusion criteria
Exclusion criteria: 1. Severe cardiovascular diseases, such as unstable angina pectoris and ischemic heart disease that are not well controlled. 2. A history of hypertension with poor blood pressure control, where elevated blood pressure may lead to serious consequences. 3. Severe hepatic and renal functional impairments. 4. Acute exacerbation of chronic obstructive pulmonary disease, hypercapnia, acute asthma attack, acute respiratory tract infection, or patients highly suspected of having a difficult airway. 5. Patients with severe mental disorders or those who have been taking psychotropic drugs for a long time. 6. Patients with deformities such as scoliosis that severely affect respiratory function. 7. Patients with a history of major thoracic or abdominal surgeries.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diaphragmatic thickness at end inspiration;End-expiratory diaphragm thickness;Diaphragmatic Thickening Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean Arterial Pressure;Heart rate;Blood oxygen saturation;Respiratory rate; | — |
Countries
China
Contacts
Public ContactYing Liu
Tianjin Binhai New Area Hospital of Traditional Chinese Medicine
Outcome results
None listed