horizontal bone defect
Conditions
Interventions
A:Control group:Bone meal&membrane pin
B:Test group:Plasma matrix bone block&membrane pin
C:Test group:Plasma matrix bone block
Sponsors
School of Stomatology Wuhan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) The participants voluntarily participate in this trial and sign a written informed consent form; (2) Age between 18 and 70 years old (inclusive of 18 and 70), gender not restricted; (3) At least one missing tooth, and the absence has lasted for more than 3 months; (4) The level of bone mass in the tooth socket at the affected area is insufficient for the diagnosed tooth loss, and the width of the alveolar crest in the affected area is between 2 and 5 mm, requiring horizontal bone augmentation to replenish bone volume; (5) The height of the available alveolar bone in the affected area of the patient is >= 8 mm; (6) The patient has the willingness and ability to control oral hygiene after receiving oral hygiene education.
Exclusion criteria
Exclusion criteria: (1) Pregnant or lactating women and patients planning to conceive during the study period; (2) Patients with contraindications to oral surgery; (3) Patients with systemic diseases that may affect the postoperative healing period and/or bone integration, such as poorly controlled diabetes (fasting blood glucose > 6.8 mmol/L), uncontrolled hypertension (systolic blood pressure >= 160 mmHg and/or diastolic blood pressure >= 100 mmHg), osteochondrosis, thyroid diseases, etc.; (4) Systemic or local bone diseases, such as bone tuberculosis, osteomyelitis, bone tumors, etc.; (5) Patients with teeth in the surgical area having periapical diseases, or teeth in the surgical area having periapical cysts; (6) Patients with uncontrolled systemic infections; (7) Severe hematological diseases, such as leukemia or other bleeding disorders; (8) Patients with uncontrolled periapical periodontal disease or advanced periodontal disease; (9) Known or suspected malignant tumors; (10) Patients with a history of radiation therapy or chemotherapy in the head and neck region within the past 3 years, or those undergoing radiation therapy or chemotherapy; (11) Patients currently taking or long-term taking special drugs that may affect postoperative healing or bone integration (such as bisphosphonate drugs and high-dose adrenal corticosteroids); (12) Patients with abnormal liver and kidney function (ALT and AST values exceeding 1.5 times the upper limit of normal, or creatinine exceeding 1.5 times the upper limit of normal); (13) Alcoholics, drug addicts or those with addictive tendencies; (14) Smokers who smoke more than 10 cigarettes per day; (15) Patients in the acute stage of hepatitis B (Big Three Positive); (16) Patients with positive initial screening for HIV antibodies, hepatitis C antibodies, and specific antibodies for Treponema pallidum; (17) Patients who do not meet the requirements for implant restoration (such as being allergic to metals); (18) Patients considered by the researchers to be unsuitable to participate in this clinical trial for other reasons; (19) Patients with vertical bone defects in the surgical area and requiring vertical bone augmentation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CBCT showed the horizontal bone width of alveolar ridge in the missing area; | — |
Secondary
| Measure | Time frame |
|---|---|
| The amount of bone absorption;Implant implantation status;Composition of new bone;Postoperative complications and postoperative adverse reactions; | — |
Countries
China
Contacts
Public ContactYufeng Zhang
School of Stomatology Wuhan University
Outcome results
None listed