Depression in the elderly
Conditions
Interventions
Cognitive function improved group:None
Cognitive function non-improved/worsened group:None
Sponsors
Hebei Mental Health Center
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Age of onset >=60 years old; (2) Meeting the DSM-5 diagnostic criteria for depressive disorder; (3) HAMD-17 score >=17; (4) Patient Health Questionnaire (PHQ-9)>=10; (5) Primary school education or above, able to understand the content of the scale; (6) MOCA scale < 26; (7) Written informed consent was obtained from the patient or his family members.
Exclusion criteria
Exclusion criteria: (1) Mini-mental state examination (MMSE) was positive; (2) Depression caused by other systemic diseases and organic brain lesions were excluded; (3) Patients with previous cranial disease, brain injury, seizures and other nervous system diseases were excluded. (4) A history of serious systemic diseases such as cardiovascular system, respiratory system, and immune system was excluded. (5) Excluding the history of alcohol and morphine abuse; (6) Excluding metal implants such as dentures, arterial clips, pacemakers or metal fixators in the body.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fMRI (Functional Magnetic Resonance Imaging) Metrics;Cognitive Function Assessment;ERP (Event-Related Potential) Indices; | — |
Secondary
| Measure | Time frame |
|---|---|
| Depression severity; | — |
Countries
China
Contacts
Public ContactLi Bing
Hebei Mental Health Center
Outcome results
None listed