ischemic stroke
Conditions
Interventions
Homocysteine-lowering treatment group:None
Sponsors
Shanxi Bethune Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Sign the informed consent form; 2. Patients with ischemic stroke confirmed by computed tomography (CT) or magnetic resonance imaging (MRI) within 72 hours of onset; 3. Aged 18-80 years; 4. Fasting blood homocysteine (Hcy) >= 10 µmol/L.
Exclusion criteria
Exclusion criteria: 1. Long-term use of folic acid/B vitamins or homocysteine (Hcy)-lowering drugs (> 1 month); 2. Stroke with other clear etiologies (e.g., cardiogenic embolism, arterial dissection, vasculitis); 3. Patients who received emergency intravenous thrombolytic therapy; 4. Severe hepatic and renal insufficiency (eGFR 3 times the upper limit of normal); 5. Severe chronic cardiopulmonary diseases, which the investigator deems unfit for participation in the project; 6. Patients with an expected life span of less than 1 year or those unable to complete the study for other reasons; 7. Lactating women, individuals with fertility plans, and patients taking methotrexate for any reason; 8. Participants in other clinical trials; 9. Presence of violent tendencies and inability to cooperate; 10. Residents not living in the area long-term and unable to cooperate with follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composite events of stroke recurrence, myocardial infarction, and vascular death; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ischemic stroke;Hemorrhage stroke;Myocardial infarction;vascular death and all cause death;Transient Ischemic Attack;Disability;Post-stroke depression;The change ranges of serum folic acid, vitamin B12, and serum homocysteine; | — |
Countries
China
Contacts
Public ContactKaili Zhang
Shanxi Bethune Hospital
Outcome results
None listed