circadian rhythm
Conditions
Interventions
Blind group:Phase I: At-Home Observation
Participants will take part while maintaining their normal work and daily routines, with all meals provided by the study team. During this phase, they will wea
Sponsors
The First Affiliated Hospital of the University of Science and Technology of China
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Totally Blind Group (30 participants): 1. Individuals who have undergone bilateral enucleation, have bilateral ocular atrophy, or have no light perception in both eyes for more than 3 years; 2. Visual acuity testing shows no light perception in both eyes; 3. Visual field testing shows no detectable field in both eyes; 4. Visual Evoked Potentials (VEP) in both eyes show no clear waveform; 5. Direct and consensual pupillary light reflexes are absent in both eyes (for those with eyes present); 6. Imaging confirms the absence of both eyes (for those with bilateral ocular atrophy or enucleation); 7. Age 18-60 years. Normal Control Group (30 participants): 1. Corrected visual acuity of both eyes >= 0.8; 2. Visual field and VEP within normal range in both eyes; 3. No history of ocular organic disease or surgery; 4. Age 18-60 years.
Exclusion criteria
Exclusion criteria: 1. Severe or poorly controlled systemic diseases, such as diabetes, hypertension, etc.; 2. Subjects unsuitable for this project due to psychological or sleep rhythm assessments; 3. Patients with a history of neurological disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| salivary melatonin circadian rhythm;body temperature circadian rhythm;Blood metabolomics data; | — |
Secondary
| Measure | Time frame |
|---|---|
| sleep-wake circadian rhythm;blood glucose circadian rhythm; | — |
Countries
China
Contacts
Public ContactYonghao Gu
The First Affiliated Hospital, University of Science and Technology of China
Outcome results
None listed