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The mechanism by which ZDHHC17 promotes cellular senescence in acute kidney injury by mediating mitochondrial transcellular transfer via CDC42 palmitoylation

The mechanism by which ZDHHC17 promotes cellular senescence in acute kidney injury by mediating mitochondrial transcellular transfer via CDC42 palmitoylation

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500115075
Enrollment
Unknown
Registered
2025-12-22
Start date
2026-01-01
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Meeting KDIGO criteria (within 48 hours: Scr increase =26.5 µmol/L or =1.5 times baseline, or urine output <0.5 mL/kg/h for 6 hours).

Interventions

Healthy control group:none

Sponsors

Ningbo Medical Centre Lihuili Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.Meeting KDIGO criteria (within 48 hours: Scr increase =26.5 µmol/L or =1.5 times baseline, or urine output = 90, normal urine routine, no systemic diseases; 6. CKD control group: CKD stages 1-3, stable kidney function for >=3 months;

Exclusion criteria

Exclusion criteria: 1.CKD 4-5(eGFR<30); 2.Treatment with hormones and immunosuppressants; 3.Severe cardiac and hepatic dysfunction; 4.Malignant tumor or expected survival <3 months; 5. Healthy control group: No organ damage, no infection/surgery/trauma in the past month, no medication use in the past two weeks; 6. CKD control group: No acute deterioration of kidney function in the past three months, no treatment with hormones or immunosuppressants, no severe heart or liver dysfunction;

Design outcomes

Primary

MeasureTime frame
Increase or decrease;Increase or decrease;Increase or decrease;

Countries

China

Contacts

Public ContactQian Dong

Ningbo Medical Centre Lihuili Hospital

lhldongqian@nbu.edu.cn+86 574 55836226

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026