Dry Eye Syndrome
Conditions
Interventions
Experimental group:Autologous plasma exosome eye drop
Sponsors
Eye Hospital, Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age range: 18 - 60 years old (inclusive). Gender is not restricted. 2. Patients with moderate to severe dry eye syndrome (in accordance with the Chinese Clinical Diagnosis and Treatment Expert Consensus on Dry Eye (2024)) who meet the diagnostic criteria, including corneal damage covering two quadrants or more, and/or corneal fluorescein staining point count >= 5, with TBUT below 5 seconds in both eyes. 3.Treatment history: Those who have not achieved satisfactory results or no effect at all from previous treatment plans for more than 3 months. 4. Voluntary participants who have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Those who planned to undergo ocular surgery within 6 months prior to the screening period or during the study period. 2. Pregnant women or lactating women. 3. Having fungal, viral or bacterial keratitis or conjunctivitis, or other active inflammatory conditions of the ocular surface. 4. Wearing contact lenses. 5. Currently suffering from ocular herpes virus or any other eye infection or having a history of ocular herpes or any other eye infection within 30 days prior to the screening. 6. Eye and surrounding allergies, etc. 7. Other conditions deemed unsuitable for participating in the trial by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Corneal fluorescein staining; | — |
Countries
China
Contacts
Public ContactChi Zailong
Eye Hospital, Wenzhou Medical University
Outcome results
None listed