Hepatocellular Carcinoma
Conditions
Interventions
Atezolizumab + Bevacizumab Combined with Locoregional Therapies:N/A
Sponsors
Zhongda Hospital, Affiliated to Southeast University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Histopathologically and/or clinically (typical imaging features) confirmed as unresectable hepatocellular carcinoma (HCC) (refer to the "Guideline for Diagnosis and Treatment of Primary Liver Cancer (2019 Edition)"); 2. Based on the diagnosis of liver cancer, has received treatment with Atezolizumab combined with Bevacizumab, along with local therapies (LRTs, including TACE, ablation, radiotherapy, or HAIC); 3. Presence of measurable intrahepatic lesions according to mRECIST criteria; 4. Liver function classified as Child-Pugh A or B; 5. Aged 18 years or older, any gender; 6. ECOG PS score <=2; 7. Complete baseline clinical and imaging data available for efficacy and safety assessment.
Exclusion criteria
Exclusion criteria: 1. Presence of other malignant tumors, or extensive extrahepatic metastasis (only isolated and controllable lung or lymph node metastases are not considered exclusion criteria); 2. Previous treatment with other systemic therapies (such as TKI drugs or immune checkpoint inhibitors) that do not align with the current study protocol; 3. Lack of key imaging or follow-up data, making it impossible to evaluate efficacy/safety; 4. Severe uncontrolled underlying diseases (such as active gastrointestinal bleeding, significantly uncontrolled ascites, serious cardiovascular diseases, active infections, etc.) that may affect prognosis or interfere with study results; 5. Pregnant or breastfeeding women; 6. Known HIV infection or acquired immunodeficiency syndrome; 7. Other conditions that the investigator deems unsuitable for study inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Real-world overall survival (OS); | — |
Countries
China
Contacts
Public ContactTeng Gaojun
Zhongda Hospital, Affiliated to Southeast University
Outcome results
None listed