Post-stroke Chronic Musculoskeletal Pain
Conditions
Interventions
Experimental Group A:Transcranial Focused Ultrasound Stimulation (Targeting M1)
Experimental Group B:Transcranial Focused Ultrasound Stimulation (Targeting PI)
Control Group:Sham Transcranial Focused Ultrasound Stimulation
Sponsors
Jing'an District Central Hospital Of Shanghai
Eligibility
Sex/Gender
All
Age
21 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Age >= 21 years old; 2) Radiological diagnosis of ischemic or hemorrhagic stroke for >= 3 months; 3) Chronic pain in the affected side of the shoulder for >= 3 months, with NRS > 4 points; 4) Mild to moderate motor dysfunction of the upper limbs (Fugl-Meyer UE = 22); 6) Those who can induce MEP by TMS are preferred to be included; 7) Sign written informed consent.
Exclusion criteria
Exclusion criteria: 1. Comorbid with other neurological diseases affecting upper limb function; 2. Severe dementia or serious psychiatric disorders prior to stroke; 3. Contraindications to MRI, TMS, or tFUS (e.g., intracranial metal implants, cardiac pacemakers, active epilepsy); 4. Acute shoulder trauma, infection, or shoulder injection within the last 3 months; 5. Pregnant or lactating women; 6. Unable to complete treatment or follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in Numeric Rating Scale (NRS) score of affected shoulder pain; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fugl-Meyer Assessment for Upper Extremity (FMA-UE);Incidence of Adverse Events (AEs);ospital Anxiety and Depression Scale (HADS) score & Montreal Cognitive Assessment (MoCA) score;Shoulder Pain and Disability Index (SPADI);Brief Pain Inventory (BPI) score;Motor Evoked Potential (MEP) amplitude and Resting-state EEG power spectrum;Shoulder Range of Motion (ROM); | — |
Countries
China
Contacts
Public ContactJia Jie
Shanghai Jing'an District Central Hospital
Outcome results
None listed