Rectal cancer
Conditions
Interventions
Colonoscopy localization group:In this study, we applied intraoperative colonoscopy to accurately localize the proximal non-irradiated colon beyond the tumor, thereby reducing the extent of resection.
Sponsors
Fujian Medical University Union Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1)Age between 18 and 80 years old (inclusive of 18 and 80); 2)Pathologically confirmed diagnosis of rectal adenocarcinoma; 3)Completion of neoadjuvant chemoradiotherapy; 4)Candidate for sphincter-preserving surgery; 5)No severe stenosis at the tumor site; the lumen allows passage of colonoscopy/gastroscopy to visualize the mucosal surface and vascular network of the proximal bowel beyond the lesion; 6)Preoperative cardiac, pulmonary, hepatic, and renal functions sufficient to tolerate surgery; 7)Preoperative ASA physical status classification of I–III; 8)The patient and family members are able to understand the study protocol, are willing to participate in this study, and have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1)Age 80 years; 2)History of inflammatory bowel disease resulting in inability to identify normal mucosa endoscopically; 3)History of other malignant tumors; 4)Patients with colorectal polyposis syndrome in whom polyps cannot be completely removed endoscopically; 5)Inadequate bowel preparation precluding endoscopic recognition of mucosa; 6)Previous placement of intestinal stents; 7)Presence of contraindications to endoscopy; 8)Inability to tolerate surgery; 9)Insufficient length of mobilized splenic flexure colon to allow safe anastomosis; 10)Other serious comorbidities that may affect postoperative recovery; 11)Simultaneous or metachronous (within 5 years) malignancy; 12)Patients with intestinal obstruction, perforation, bleeding, or other conditions requiring emergency surgical resection; 13)History of previous pelvic or urinary system surgery; 14)ASA physical status classification IV or V; 15)Severe psychiatric disorders; 16)Severe emphysema, interstitial pneumonia, or ischemic heart disease rendering the patient unable to tolerate surgery; 17)History of unstable angina or myocardial infarction within 6 months; 18)History of cerebral infarction or cerebral hemorrhage within 6 months; 19)Continuous systemic corticosteroid therapy within 1 month; 20)Patient or family members unable to understand the conditions and objectives of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pathological scoring differences between sites with normal mucosal vascular pattern and sites with unclear mucosal vascular pattern under colonoscopy in radiation enteritis.; | — |
Secondary
| Measure | Time frame |
|---|---|
| incidence of anastomotic leakage;overall complication incidence;preoperative and postoperative anal function; | — |
Countries
China
Contacts
Public ContactZhifen Chen
Fujian Medical University Union Hospital
Outcome results
None listed