severe non-proliferative diabetic retinopathy
Conditions
Interventions
Experimental Group:Pars plana vitrectomy
Panretinal Photocoagulation
Sponsors
Huashan Hospital Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 80 years; 2. Diagnosed with subretinal neovascular diabetic retinopathy (sNPDR); 3. Requiring photocoagulation for sNPDR; 4. Type 1 or Type 2 diabetes mellitus (glycaemic control managed per endocrinologist's requirements); 5. Best-corrected visual acuity (BCVA) > 0.05 (20/400); 6. Willingness to sign an informed consent form and attend follow-up appointments as scheduled by the research institute.
Exclusion criteria
Exclusion criteria: 1. Medication-controlled blood pressure exceeding 180/110 mmHg, eGFR < 15 or renal failure/dialysis, myocardial infarction, heart failure, systemic anti-VEGF therapy; 2. Target eye previously treated with PRP, PPV; intraocular anti-VEGF injections within the preceding three months, peribulbar/intraocular corticosteroids, posterior capsular laser treatment for epiretinal membrane; 3. Aphakic eye where PRP is contraindicated due to optical media opacity; non-diabetic macular oedema; optic nerve injury; endophthalmitis; primary glaucoma; or other ocular conditions affecting diabetic retinopathy progression.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| occurence of PDR within one year.; | — |
Secondary
| Measure | Time frame |
|---|---|
| BCVA;central retina thickness;visual field; | — |
Countries
China
Contacts
Public ContactZhiliang Wang
Huashan Hospital Fudan Univiersity
Outcome results
None listed