depression
Conditions
Interventions
Accelerated Transcranial Magnetic Stimulation Intervention Group:Right orbitofrontal cortex (OFC) stimulation was delivered using 1-Hz low-frequency pulses at an intensity of 90% of the resting motor
Sham Intervention Group:All stimulation protocols and pulse parameters were identical to those of the active intervention group, but were delivered using a sham stimulation coil to achieve a placebo-c
Sponsors
The Second People’s Hospital of Guizhou Province
Eligibility
Sex/Gender
All
Age
15 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Primary DSM-5 diagnosis of moderate to severe depression, either first-episode or recurrent; 2. Aged 15–60 years, male or female; 3. HAMD-17 score >=17; 4. Moderate to severe treatment-resistant depression, Maudsley Rating Scale score >7; 5. Stable medication regimen for over 4 weeks prior to treatment, maintained throughout trial; 6. Capable of providing informed consent and adhering to treatment protocol; 7. Beck Suicide Rating Scale score >12.
Exclusion criteria
Exclusion criteria: 1.Presence of other psychiatric disorders, such as personality disorders, substance dependence, anxiety disorders, manic episodes, or schizophrenia. 2.Receipt of electroconvulsive therapy (ECT) or repetitive transcranial magnetic stimulation (rTMS) during the current depressive episode, or prior non-response to single-site TMS. 3.Non-response to an adequate course of electroconvulsive therapy (at least eight sessions). 4.Unstable vital signs or severe neurological disorders. 5.Contraindications to TMS or MRI (e.g., history of epilepsy, implanted metal stents, pacemakers). 6.Any condition, present now or anticipated, that may compromise patient safety or interfere with successful participation in the study (including medical, psychological, social, or geographic factors). 7.Pregnant or breastfeeding women. 8.Prior use of investigational drugs or medical devices, or current participation in another interventional study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BSI-CV scores;Hamilton Depression Rating Scale, 24-item version (HAMD-24); | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Rating Scale (HAMA);Dimensional Anhedonia Rating Scale (DARS);Cognitive evaluation;Montgomery–?sberg Depression Rating Scale (MADRS);Adverse events;Patient Health Questionnaire-9 (PHQ-9);Generalized Anxiety Disorder-7 (GAD-7); | — |
Countries
China
Contacts
Public ContactHu Lingyan
The Second People's Hospital of Guizhou Province
Outcome results
None listed