Autoimmune Gastritis
Conditions
Interventions
immediate H. pylori eradication group:Research participants randomized to the immediate H. pylori eradication group will receive a standard course of bismuth-containing quadruple therapy promptly afte
Delayed H. pylori Eradication Group:Participants in this group will first enter a 12-month standard clinical follow-up period upon enrollment, during which symptomatic/supportive care is permitted. Th
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Aged 18 to 75 years, regardless of gender. Meeting the diagnostic criteria for both Autoimmune Gastritis (AIG) and H. pylori infection. Provision of written informed consent.
Exclusion criteria
Exclusion criteria: 1. History of prior H. pylori eradication therapy, or current use of antibiotics or proton pump inhibitors (PPIs) within the past 4 weeks. 2. Presence of severe dysplasia, intraepithelial neoplasia, gastric cancer, or gastric neuroendocrine tumors observed during the screening endoscopy. 3. History of gastric cancer or major gastrectomy. 4. Requirement for long-term, continuous use of medications including proton pump inhibitors (PPIs), non-steroidal anti-inflammatory drugs (NSAIDs), or corticosteroids. This also includes patients with other systemic autoimmune diseases (e.g., systemic lupus erythematosus, myasthenia gravis) whose condition may confound the study outcomes. 5. Severe hepatic or renal dysfunction, cardiac insufficiency, or active malignancy. 6. Known allergy or hypersensitivity to any component of the study medications. 7. Pregnant or breastfeeding women. 8. Inability to comply with the scheduled follow-up procedures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Histological Improvement Rate;Disease Progression Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum Autoantibody Levels;Gastric Acid Secretory Function;Anemia and Nutritional Indices;Clinical Symptoms and Quality of Life;H. pylori Eradication Rate; | — |
Countries
China
Contacts
Public ContactZhu Wang
West China Hospital of Sichuan University
Outcome results
None listed