End-stage osteoarthropathy of the knee
Conditions
Interventions
Group with two applications of intravenous dexamethasone:Intravenous dexamethasone at induction of anaesthesia (preoperative) and postoperatively
Group with one applications of intravenous dexamethasone:Induction of anaesthesia (preoperative) via intravenous dexamethasone
Intravenous combined topical dexamethasone group:Intravenous co-topical dexamethasone
Topical dexamethasone group:Intraoperative local infiltration of the joint cavity with dexamethasone injection
blank control group:No other additional treatment
Sponsors
the Second Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients with end-stage arthritis of the knee and scheduled to undergo an initial unilateral TKA; 2.Age greater than 50 years;
Exclusion criteria
Exclusion criteria: 1.Patients with prior hypersensitivity to dexamethasone or a history of contraindication to dexamethasone; 2.Patients using opioids or dexamethasone within three months prior to surgery; 3.Patients with active peptic ulcer disease, psychological or neurological disorders affecting pain perception; 4.Patients with rheumatoid disease, systemic lupus erythematosus, or ankylosing spondylitis who have been on hormone therapy for the past six months; 5.Patients undergoing TKA for infectious reasons;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of occurrences of postoperative nausea and vomiting (PONV);Pain scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Use of rescue analgesics;Neutrophil ratio;Quality of Recovery Score (QoR15);CRP;postoperative complication;Knee Society Functionality Score;Range of motion;Post-operative length of stay;white blood cell count;IL-6;Degree of knee swelling;erythrocyte sedimentation rate;Use of Emergency Anti-Vomiting Medications; | — |
Countries
China
Contacts
Public ContactXu Wei
the Second Affiliated Hospital of Soochow University
Outcome results
None listed