Parkinson's disease
Conditions
Interventions
Research group:None
Control group:None
Sponsors
The First Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Research Group: 1. Patients diagnosed with primary Parkinson's disease (PD) according to the "Diagnostic Criteria for Parkinson's Disease in China (2016)", aged between 50 and 75 years old, and at Hoehn-Yahr stages 2 to 4; 2. Patients with PD who meet the surgical indications of the "Expert Consensus on Deep Brain Stimulation Therapy for Parkinson's Disease in China (Second Edition, 2022)" and have undergone bilateral subthalamic nucleus deep brain stimulation surgery; 3. Postoperative target reconstruction shows that the DBS electrode implantation position is accurate; 4. Right-handed; 5. Voluntarily participate in this study and sign the consent form, and be able to independently complete the scale assessment and cooperate with the follow-up related examinations and evaluations. 2.Control group: 1. Subjects between the ages of 50 and 75 years, matching the age, sex, and education level of the case group, right-handed, and without neurosystem-related diseases; 2. Informed understanding, voluntary participation in the study and signed consent;
Exclusion criteria
Exclusion criteria: 1. Clinically diagnosed with dementia or severe cognitive impairment; 2. There are serious (refractory) anxiety, depression, schizophrenia and other mental diseases; 3. Diseases affecting brain function and nervous system (severe cerebrovascular diseases, epilepsy, brain trauma, etc.); 4. Major physical diseases (such as hyperthyroidism, metastatic tumors, etc.); 5. History of substance abuse (drugs, alcohol, etc.); 6. Hearing impairment, eye disease, etc., can not cooperate with the follow-up examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MDS Unified-Parkinson Disease Rating Scale, MDS-UPDRS;Freezing of Gait Questionnaire, FOG-Q;Brain Function Assessment: Resting-state and near-infrared functional imaging data under different motor paradigms; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-mental state examiniation, MMSE;Montreal Cognitive Assessment, MoCA;amilton Anxiety Scale, HAMA;Hamilton Depression Scale, HAMD;Fatigue Severity Scale, FSS;Rapid Eye Movement Sleep Behavior Disorder Screening Questionnaire,RBD-SQ;Medication Details: Including drug name, dosage, and levodopa equivalent dose.; | — |
Countries
China
Contacts
Public ContactLiang Zhanhua
The First Affiliated Hospital of Dalian Medical University
Outcome results
None listed