Gynecological diseases with tumors or some severe adhesions and large masses
Conditions
Interventions
Bupivacaine liposomal group:Bilateral transverse abdominis plane combined rectus abdominis sheath block with liposomal bupivacaine
Ropivacaine group:Ropivacaine was used for bilateral transverse abdominis plane combined rectus abdominis sheath block
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Age 18~65 years old; (2) Patients undergoing elective gynecological laparotomy; (3) ASA grade II.~III.; (4) General health and normal cardiopulmonary function before surgery; (5) The patient signs the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Hypersensitivity to bupivacaine liposomes or other anesthetic drugs used in this study; (2) Cardiac insufficiency, ECG abnormalities such as atrial fibrillation; (3) History of severe hypertension, coronary heart disease, diabetes, bronchial asthma, etc.; (4) liver and kidney insufficiency (5) infection, inflammation or injury at the puncture site; (6) Have a history of chronic pain.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Opioid dosage at 72 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score;Time of first postoperative PCA press;Number of postoperative PCA presses;Frequency of rescue analgesic medication use;Time to first ambulation after surgery;Number of mobilizations within 48 hours;Adverse reactions (vomiting, pruritus, etc.);Length of hospital stay;Quality of Recovery-15 (QoR-15) assessment scale ; | — |
Countries
China
Contacts
Public ContactLei Enjun
The First Affiliated Hospital of Nanchang University
Outcome results
None listed