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The Effect of Timing of Subanesthetic Dose Esketamine Administration on Emergence Agitation in Patients Undergoing Endoscopic Nasal Surgery: A Single-Center Randomized Controlled Study

The Effect of Timing of Subanesthetic Dose Esketamine Administration on Emergence Agitation in Patients Undergoing Endoscopic Nasal Surgery: A Single-Center Randomized Controlled Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500115004
Enrollment
Unknown
Registered
2025-12-19
Start date
2026-01-01
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Emergence Agitation (EA)

Interventions

The control group (Group C):Received an equal volume of saline before induction and 20 min before the end of surgery.
The group receiving medication before induction (Group E1):Received 0.25 mg/kg esketamine before induction and an equal volume of saline 20 min before the end of surgery.
The group receiving medication 20 minutes before the end of the surgery (Group E2).:Received an equal volume of saline before induction and 0.25 mg/kg esketamine 20 min before the end of surgery.

Sponsors

The First Affiliated Hospital of Shan Tou University Medical College
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Patients scheduled for nasal surgery under general anesthesia; 2.Aged 18 years or older; 3.ASA physical status class I or II;

Exclusion criteria

Exclusion criteria: 1.Patients with severe damage to vital organs (such as heart, liver, kidney, etc.); 2.Patients with severe or uncontrolled hypertension; 3.Patients with allergy to esketamine; 4.Patients with a history of drug abuse; 5.Patients with a history of neuropsychiatric symptoms or disorders; 6. Patients with ASA >= III.

Design outcomes

Primary

MeasureTime frame
Emergence agitation score;

Countries

China

Contacts

Public ContactQiu Zeting

The First Affiliated Hospital of Shanou Univercity Medical College

doctorqiuzt@gmail.com+86 13580546462

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026