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Comparison of the effects of bupivacaine liposome and bupivacaine hydrochloride on postoperative pain and delirium in patients undergoing anterior lumbar psoas space block for hip replacement surgery

Comparison of the effects of bupivacaine liposome and bupivacaine hydrochloride on postoperative pain and delirium in patients undergoing anterior lumbar psoas space block for hip replacement surgery

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500114990
Enrollment
Unknown
Registered
2025-12-19
Start date
2025-12-22
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hip fracture

Interventions

The bupivacaine liposome ( AIMSB group is abbreviated as the AL group):About 30 minutes before the operation, the patient received anterior iliopsoas muscle space block, 40ml/266mg bupivacaine liposom
Bupivacaine hydrochloride AIMSB group, abbreviated as AB group:About 30 minutes before the operation, the patient received anterior iliopsoas muscle space block using 40ml of 0.25% bupivacaine hydroch

Sponsors

Chengdu Fifth People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1.Aged 65 to 85; 2.A primary, unilateral, non-anterior hip replacement surgery is proposed; 3.ASA classification grades I to III

Exclusion criteria

Exclusion criteria: 1. Infection at the puncture site; 2. Pre-existing neurological deficits in the lower limbs; 3. History of allergy to local anaesthetics; 4. Coagulation disorders; 5. Significant hepatic, renal, or cardiac dysfunction; 6. Dementia, psychiatric, or neurological disorders; 7. Substance dependence or routine use of analgesics; 8. Refusal to cooperate with research personnel.

Design outcomes

Primary

MeasureTime frame
The NRS(numerical rating scale) score at 40-60° flexion of the leg 24 hours after the operation;The incidence of delirium 3 days after surgery;

Secondary

MeasureTime frame
Subtypes of delirium (low-activity type, high-activity type, mixed type);The rest of the time is scored on the numerical rating scale, NRS;The use of intraoperative analgesics;The number of postoperative analgesic remedies;The use of vasoactive drugs during the operation;Adverse reactions occurred after awakening and in the recovery room;Evaluation of postoperative recovery quality score (QoR-15);postoperative complications;operation time;The time of first getting out of bed;Recovery time of gastrointestinal function;

Countries

China

Contacts

Public ContactCAI MIN

Chengdu Fifth People's Hospital

420686875@qq.com+86 137 3084 2311

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026