Primary hypertension
Conditions
Interventions
Ultrasound group:Ultrasound group
Radiofrequency group (RF group):Radiofrequency group (RF group)
Sponsors
SUN YAT-SEN MEMORIAL HOSPITAL
Eligibility
Sex/Gender
All
Age
18 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1.Age >=18 years and =3 months, after treatment with protocol-specified antihypertensive medications for at least 28 days (at least two types), clinic SBP >=140mmHg and clinic DBP >=90mmHg, with concurrent 24h-SBP >=135mmHg; 3.Agree to comply with the research process and sign informed consent.
Exclusion criteria
Exclusion criteria: 1.Patients with secondary hypertension; 2.History of previous renal artery interventional treatment, such as stenting, etc.; renal artery lesions or morphological variants, including: aneurysm, stenosis, severe renal artery calcification, dissection, multiple renal arteries, etc.; 3.Occurrence of myocardial infarction, unstable angina, syncope, cerebrovascular accident, intermittent claudication, extensive atherosclerosis with history of intravascular thrombosis within the recent 6 months; 4.Concurrent cardiac valvular disease with significant hemodynamic changes; 5.Concurrent refractory pulmonary hypertension; 6.Estimated glomerular filtration rate (eGFR) 1.5); 8.History of ICD (implantable cardioverter defibrillator); 9.Acute or severe systemic infection; 10.Concurrent type 1 diabetes mellitus;Other diseases requiring long-term oxygen therapy or mechanical ventilation besides nocturnal sleep apnea; 11.Contrast agent allergy; 12.Pregnant, lactating, or women planning pregnancy; 13.Alcohol and other substance addiction, psychiatric patients; 14.Other diseases that may adversely affect subject or clinical study safety; 15.Patients already participating in other drug or device clinical studies; 16.Patients deemed unsuitable for participation in this clinical study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-hour ambulatory blood pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Office blood pressure; | — |
Countries
China
Contacts
Public ContactHaifeng Zhang
SUN YAT-SEN MEMORIAL HOSPITAL
Outcome results
None listed