Elderly patients with hip fractures
Conditions
Interventions
Control Group :Sufentanil was used for analgesia after the operation
Tegileridine Group:Postoperative analgesia was administered with Tegileridine
Sponsors
The First Affiliated Hospital of University of Science and Technology of China
Eligibility
Sex/Gender
All
Age
65 Years to 86 Years
Inclusion criteria
Inclusion criteria: 1. Patients with hip fractures scheduled for elective total hip arthroplasty; 2. Aged >=65 years and 23 and Montreal Cognitive Assessment (MoCA) score >=26; 7. Voluntarily signed informed consent and willing to comply with the study protocol requirements.
Exclusion criteria
Exclusion criteria: 1. Patients with major organ or systemic diseases, uncontrolled hypertension, diabetes, coronary heart disease, or malignant tumors; 2. Patients with hypoalgesia or hyperalgesia, a history of chronic analgesic use, or a history of alcoholism; 3. Patients unable to complete postoperative MoCA and MMSE assessments, or with a history of psychiatric disorders; 4. Patients who have experienced any cerebrovascular events within the past 3 months, such as stroke or transient ischemic attack (TIA); 5. Patients with severe infections; 6. Patients with preoperative PaO2< 60 mmHg or SpO2< 92%; 7. Patients who have participated in another drug clinical trial within the past 30 days; 8. Patients who refuse to use a PCA pump for postoperative pain management; 9. Patients with a known allergy to the investigational drug(s).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep quality assessment;Perioperative pain score;Postoperative adverse reactions; | — |
Countries
China
Contacts
Public ContactMeng Yan
The First Affiliated Hospital of University of Science and Technology of China
Outcome results
None listed