Obesity
Conditions
Interventions
GLP-1 receptor agonist medication group:None
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Aged 18-50 years; Body Mass Index (BMI) >=28; Voluntarily selected GLP-1 receptor agonist treatment with no contraindications; and voluntarily participated in this project with signed informed consent.
Exclusion criteria
Exclusion criteria: Presence of severe cardiac or skeletal muscle disease, or sarcopenia (defined as grip strength <28 kg for males or <18 kg for females, combined with an appendicular skeletal muscle index <7.0 kg/m² for males or <5.7 kg/m² for females); history of bariatric surgery; prior use of GLP-1 receptor agonists within the past year; comorbid severe underlying medical conditions or disabilities affecting physical activity; or mental/psychological disorders (e.g., diagnosed psychiatric conditions, cognitive impairment).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Left Ventricular Myocardial Mass Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Grip strength;Skeletal Muscle Mass Index; | — |
Countries
China
Contacts
Public ContactYin Yuan
West China Hospital of Sichuan University
Outcome results
None listed