Lung cancer
Conditions
Interventions
Gold Standard:Pathological diagnosis
Index test:Early Screening System for Lung Cancer-Related Gene Methylation Based on Electrochemical-Surface Plasmon Resonance Technology (ESPR)
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Retrospective Cohort 1. Healthy Control Group (N = 124): No history of lung cancer or family history of tumors before sample collection, and no long-term smoking history (smoking index = 20 pack-years; first-degree relative with a family history of lung cancer; presence of COPD, diffuse pulmonary fibrosis, or old pulmonary tuberculosis; history of previous malignancy; long-term exposure to secondhand smoke (at home or workplace, >2 hours/day, for at least 10 years) or long-term exposure to kitchen cooking fumes (stir-frying, pan-frying, deep-frying, etc.).
Exclusion criteria
Exclusion criteria: Retrospective Cohort Healthy Control Group (N = 124): coexisting with other malignant tumors; severe immunosuppression; pregnancy/lactation; received blood transfusion or immunotherapy within 1 month before blood collection. Early Lung Cancer Group (N = 124): coexisting with other malignant tumors; HIV infection or post-organ transplantation; used demethylating agents within 72 hours before sample collection. Prospective Cohort 1. Coexisting with other malignant tumors not clinically cured; 2. Severe immunosuppression; 3. Pregnancy/lactation; 4. Received blood transfusion or immunotherapy within 1 month before blood collection; 5. HIV infection or post-organ transplantation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Methylation levels of lung cancer-related genes;Sensitivity;Specificity;Positive Predictive Value (PPV);Negative Predictive Value (NPV);Hazard Ratio (HR) ; | — |
Countries
China
Contacts
Public ContactLi Lin
Beijing Hospital
Outcome results
None listed