Cervical intraepithelial neoplasia grade II, cervical intraepithelial neoplasia grade III, cervical carcinoma in situ, high-risk human papillomavirus (HR-HPV) infection
Conditions
Interventions
persistent HR-HPV infection group:None
HR-HPV negative conversion group:None
Sponsors
The International Peace Maternity and Child Health Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Underwent cervical loop electrosurgical excision procedure (LEEP) at our hospital's cervical clinic, with preoperative colposcopy-directed biopsy or postoperative LEEP pathology confirming high-grade cervical intraepithelial neoplasia (HSIL, CIN2, or CIN3); 2. Completed HR-HPV genotyping tests both before and after surgery, with at least one positive HR-HPV result, and with traceable laboratory test results; 3. Postoperative follow-up of at least 18 months, with at least 2 follow-up visits (each including HPV genotyping and cervical cytology re-examination); 4. Complete clinical data, including age, menopausal status, obstetric history, cervical cytology, colposcopic findings, pathology results, and postoperative follow-up information.
Exclusion criteria
Exclusion criteria: 1.incomplete key information (e.g., negative preoperative HPV, unknown HPV genotyping, interrupted follow-up or loss to follow-up; 2.Patients who underwent total hysterectomy, cervical cryotherapy, laser therapy, photodynamic therapy, or other local adjuvant therapies within 6 months after cervical LEEP; 3.Patients who underwent LEEP during pregnancy or within 8 weeks postpartum; 4.A history of invasive cervical treatment (including LEEP, conization, cryotherapy, or laser therapy) in the past; 5.A previous diagnosis of cervical cancer or other malignant tumors of the reproductive tract; 6.A history of pelvic radiotherapy or systemic chemotherapy; 7.Long-term use of immunosuppressants or complicated with immune system diseases (e.g., systemic lupus erythematosus, HIV infection, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Infection status of different HR-HPV types after cervical LEEP surgery ; | — |
Secondary
| Measure | Time frame |
|---|---|
| High-risk factors for disease residue or recurrence in patients after cervical LEEP surgery; | — |
Countries
China
Contacts
Public ContactWang Liya
The International Peace Maternity and Child Health Hospital
Outcome results
None listed