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Real world study on the impact of periodontitis on the efficacy of immunotherapy for head and neck squamous cell carcinoma

Real world study on the impact of periodontitis on the efficacy of immunotherapy for head and neck squamous cell carcinoma

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500114950
Enrollment
Unknown
Registered
2025-12-19
Start date
2026-01-01
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Head and Neck Squamous Cell Carcinoma

Interventions

No/Mild periodontitis group:None
Moderate/Severe periodontitis group:None

Sponsors

Shandong University Qilu Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Diagnosed with head and neck squamous cell carcinoma through pathology, and according to RECIST 1.1, there is at least one measurable target lesion. 2. Receive immunotherapy. 3. Cooperate with periodontal and imaging examinations during the study period. 4. Voluntarily participate in this study, have good compliance, and sign an informed consent form.

Exclusion criteria

Exclusion criteria: 1. Baseline examination shows that the periodontal opening is less than 2cm. 2. Complete edentulism or implant restoration>50%.

Design outcomes

Primary

MeasureTime frame
Objective Response Rate;—

Secondary

MeasureTime frame
Attachment Loss;Bone Loss;Tumor Size;Probing Depth ;Disease Control Rate;Overall Survival;Progression-Free Survival;—

Countries

China

Contacts

Public ContactYang Chengzhe

Shandong University Qilu Hospital

yangchengzhe@email.sdu.edu.cn+86 185 6008 5061

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026