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Effect of bupivacaine liposome treatment of thoracic paravertebral nerve block on postoperative psychological symptoms in patients undergoing thoracoscopic surgery-A prospective, double-blind, randomized controlled study

Effect of bupivacaine liposome treatment of thoracic paravertebral nerve block on postoperative psychological symptoms in patients undergoing thoracoscopic surgery-A prospective, double-blind, randomized controlled study

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500114947
Enrollment
Unknown
Registered
2025-12-19
Start date
2026-01-01
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative psychological symptoms (anxiety, depression, stress, and sleep).

Interventions

Ropivacaine paravertebral nerve block:Ropivacaine paravertebral nerve block
Bupivacaine liposomal paravertebral nerve block group:Bupivacaine liposomal paravertebral nerve block

Sponsors

Qingdao Municipal Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.50 years old< age < 80 years old; ASAI.-III; 2.There is no limit to men and women; 3.Patients undergoing thoracoscopic surgery were selected; 4.Before the trial, understand the nature, significance, possible benefits, possible inconveniences and potential dangers of the trial, understand the study procedures, and voluntarily sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Pregnant or lactating women and those who have a birth plan within 3 months; 2.Those with obvious respiratory and circulatory dysfunction, blood routine and blood biochemical indicators before surgery; 3.Those with severe neuropsychiatric diseases; 4.Allergic or contraindicated to drugs such as bupivacaine liposomes and their components; 5.Taking antidepressants, anxiolytics or other psychotropic drugs for a long time (more than 3 months); 6.Unable to understand or refuse to complete the questionnaire; 7. Patients who cannot obtain informed consent, or who are considered by the investigator to be inappropriate to participate in this trial.

Design outcomes

Primary

MeasureTime frame
To assess the patient's postoperative psychological symptoms (anxiety, depression, stress and sleep).;

Secondary

MeasureTime frame
Patients had a daily equivalent dose of morphine, an opioid analgesic, for 3 days postoperatively;Length of patient hospital stay;Pain scores (NRS) at rest and during coughing for patients 3 days postoperatively;

Countries

China

Contacts

Public ContactWang Bin

Qingdao Municipal Hospital

wangbin328@sina.com+86 132 9542 6246

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026