Burns
Conditions
Interventions
Probiotic group:Actobacillus plantarum are administered orally or naso-gasped
Control Group:Probiotic mimicry for oral or nasal feeding
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years, with generally good health history; 2. Admitted within 72 hours after burn; 3. Severe burn patients (total burn area >20% or third-degree burn area >10%).
Exclusion criteria
Exclusion criteria: 1. Patients with severe trauma such as major hemorrhage, cranial injury, hemopneumothorax, severe fractures, major organ damage, or those who experienced shock before admission; 2. Patients who experienced gastrointestinal symptoms such as vomiting, abdominal pain, diarrhea, or constipation before enrollment; 3. Patients with digestive system diseases such as gastrointestinal tumors, IBS, IBD, or fatty liver disease; 4. Patients with diabetes (history of diabetes or random blood glucose >=11.1mmol/L, fasting blood glucose >=7.0mmol/L, HbA1c >=6.5%), obesity (BMI >27.9), cardiovascular disease (severe heart disease, myocardial infarction, unstable angina, NYHA class III or IV), neurological or psychiatric disorders (anxiety, depression, autism, Alzheimer's disease, etc.), or autoimmune diseases; 5. Patients with severe liver or kidney dysfunction (ALT, AST more than twice the normal value, or total serum bilirubin >1.5 times the upper normal limit, serum creatinine or blood urea nitrogen >1.25 times the normal value, or creatinine clearance <70 mmol/L); 6. Patients who had taken probiotics or long-term antibiotics before admission; 7. Patients with severe infections or immunodeficiency disorders; 8. Individuals who abuse drugs or narcotics, or have a long-term history of heavy smoking or alcohol consumption; 9. Patients with a history of allergy to probiotics or with allergic constitution; 10. Patients with mental or neurological disorders who cannot express their intentions correctly; 11. Women who are breastfeeding, pregnant, or planning pregnancy; 12. Participants in other drug clinical trials within the past three months; 13. Patients deemed unsuitable for clinical trials by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intestinal flora;Symptoms of intestinal dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Wound healing rate;Complication rates of shock, infection, sepsis, etc; | — |
Countries
China
Contacts
Public ContactHongyan Zhang
The First Affiliated Hospital of Nanchang University
Outcome results
None listed