Allergic rhinitis
Conditions
Interventions
Blank group:None
Control group:None
Observation Group:None
Sponsors
Meishan People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged between 14 and 60 years; 2. Willing to pay for dynamic testing of serum-specific sIgE and total IgE to evaluate treatment effectiveness and future treatment value, and able to cooperate with clinical nasal examinations, SPT, audiological tests, and rating scales at each mid-term research visit; 3. Medical history shows no hearing loss, no history of noise exposure, no history of ototoxic drug use, no metabolic disorders, and no neurological problems; 4. Audiology and otoscopic examinations show normal cochlear and middle ear function. Participants with double mite positive results of 2 or higher on SPT or positive dust mite-specific IgE will be enrolled in the observation group; if SPT or serum-specific IgE results are negative, they will be enrolled in the blank group; 5. The patient or the patient’s family must fully understand the AR treatment plan, have a thorough understanding of the SLIT process, possible risks, and contraindications, and voluntarily choose SLIT; 6. Patients who can adhere to SLIT and maintain regular follow-up.
Exclusion criteria
Exclusion criteria: 1. Age under 14 or over 60; 2. Patients with a history of external ear trauma, use of ototoxic drugs, any systemic or metabolic disorders leading to hearing loss, tympanic membrane perforation, other middle ear pathologies, or previous ear surgeries; 3. Inability to cooperate with clinical nasal local examination, SPT, audiological tests, or rating scales; 4. SLIT patients who drop out midway or are unable to cooperate with follow-up should be excluded; 5. Those who refuse to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Audiology tests (average hearing threshold, tympanometry, otoacoustic emission signal-to-noise ratio, acoustic reflex threshold, ABR); | — |
Secondary
| Measure | Time frame |
|---|---|
| Skin Prick Test (SPT) Results;Serum-specific sIgE (against house dust mites/dust mites); | — |
Countries
China
Contacts
Public ContactLiu Danfeng
Meishan People's Hospital
Outcome results
None listed