retardation major depressive disorder
Conditions
Interventions
Supplementary Motor Area group:Supplementary Motor Area TMS
DLPFC group:DLPFC TMS
Healthy control group:NA
Sponsors
Beijing Anding Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: MDD: 1. Patients aged 18 to 65 years (inclusive) who are outpatients or inpatients, regardless of gender. 2. In accordance with the diagnostic criteria for Major Depressive Disorder (MDD) as outlined in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5); 3. Hamilton Depression Scale, HAMD-17 >=14; 4. Both first-episode and recurrent cases; 5. Patients with first-episode who are drug-naïve, or who have discontinued medication for 2 weeks prior to enrollment, or who have been on a stable medication regimen for 2 weeks prior to enrollment; 6. HAMD-8th score >=1; 7. Be able to understand and voluntarily agree to participate in this study, and to comply with the treatment procedures. Be willing to sign the informed consent form; HC: 1. Aged 18 to 65 years (inclusive) who are outpatients or inpatients, regardless of gender. 2. Primary school education or above, able to understand the research content; 3. Had no history of somatic diseases in the cardiovascular, respiratory, digestive, renal, endocrine, or hematological systems. 4. No history of psychiatric disorders. 5. Be able to understand and voluntarily agree to participate in this study, and to comply with the treatment procedures. Be willing to sign the informed consent form;
Exclusion criteria
Exclusion criteria: MDD: 1. Current or past diagnosis of another mental disorder that meets DSM-5 criteria; 2. Subjects who have participated in any interventional clinical trials in the past 3 months. 3. Excessive head motion during the fMRI scan (i.e., translation greater than 3 mm or rotation greater than 3 degrees, with a mean framewise displacement greater than 0.8 mm). 4. Failed to complete the scan due to other reasons, such as claustrophobia; 5. MoCA score =2; 7. Serious organic disease or history of organic disease. HC: 1. Presents with a psychiatric disorder. 2. History of impaired consciousness, or psychiatric disorders such as schizophrenia, bipolar disorder, depressive disorder, or personality changes. 3. Family history of genetic diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale ; | — |
Secondary
| Measure | Time frame |
|---|---|
| COLUMBIA-SUICIDE SEVERITY RATING SCALE (C-SSRS);Quick Inventory of Depressive Symptomatology-Self-Report (QIDS-SR);Young Mania Rating Scale (YMRS);Hamilton Anxiety Rating Scale (HAMA); | — |
Countries
China
Contacts
Public ContactZang Zhenxiang
Beijing Anding Hospital, Capital Medical University
Outcome results
None listed